Hyperuricemia - high uric acid in the blood . The maximum value for the normal level is 360 micromol / liter (6 mg / dL) for women and 420 micromol / liter (6.8 mg / dL) for men [2] . Hyperuricemia often accompanies diseases such as gout , Lesch-Nyhan syndrome , etc.
| Hyperuricemia | |
|---|---|
 uric acid | |
| ICD-10 | E 79.0 |
| ICD-9 | 790.6 |
| ICD-9-KM | |
| DiseasesDB | 5375 |
| eMedicine | med / 1112 |
| Mesh | and |
Content
Reasons to
Hyperuricemia develops in connection with a violation of the exchange of purine nucleotides . The reasons for the increased uric acid in the blood are as follows:
- Increased formation of uric acid (with gout; with excessive consumption of purine nitrogenous bases and nucleoproteins with food, coupled with a sedentary lifestyle; and, according to some sources, because of the increased content of fructose in food [3] [4] ).
- Reduction of renal excretion (excretion) of uric acid as a result of a malfunction of the kidneys (with primary gout, with glomerulonephritis, kidney amyloidosis, alcohol intoxication, etc.).
- Hyperactivation of PRPT-synthetase in violation of the inhibition of its activity.
- Hypoxanthine-guanine-phosphoribosyltransferase deficiency, or HGFRT (an enzyme that provides for the reutilization of purine bases), which manifests itself, for example, in Lyosha-Nihena syndrome . This leads to the fact that hypoxanthine (which was formed as a result of degradation of nucleotides) does not convert to IMP (that is, the recycling processes are disturbed), begins to accumulate and, as a result of consecutive reactions under the action of xanthine oxidase, is converted into uric acid.
- Glycogenosis Girke.
Treatment
- The drug "Aquaretics".
- The drug " Allopurinol " (200-300 mg orally once a day).
- A diet low in purine bases and nucleoproteins.
- The drug "Febuxostat" [5] .
See also
- Gout
- Lesch-Nyhan syndrome
Notes
- ↑ Monarch Disease Ontology release 2018-06-29sonu - 2018-06-29 - 2018.
- ↑ Chizyński K., Rózycka M. Hyperuricemia (Polish) // Pol. Merkur. Lekarski. - 2005. - Vol. 19 , No. 113 . - p . 693-696 . - PMID 16498814 .
- ↑ Nakagawa T., Hu H., Zharikov S., et al . A causal role for uric acid in fructose-induced metabolic syndrome (English) // American Journal of Physiology . - 2006. - Vol. 290 , no. 3 - P. F625-31 . - DOI : 10.1152 / ajprenal.00140.2005 . - PMID 16234313 .
- ↑ Mayes PA Intermediary metabolism of fructose (Eng.) // The American Journal of Clinical Nutrition . - 1993. - Vol. 58 , no. 5 Suppl . - P. 754S — 765S . - PMID 8213607 .
- ↑ Becker MA, Schumacher HR, Wortmann RL, et al . Febuxostat compared with allopurinol in patients with hyperuricemia and gout (Eng.) // The New England Journal of Medicine : journal. - 2005. - Vol. 353 , no. 23 . - P. 2450-2461 . - DOI : 10.1056 / NEJMoa050373 . - PMID 16339094 .
Links
- Hyperuricemia in the Big Medical Encyclopedia (BME) , edited by Petrovsky B.V., 3rd edition
- Medical base of family doctors (English)
- The content of purine in food (eng.)