Hyperuricemia - high uric acid in the blood . The maximum value for the normal level is 360 micromol / liter (6 mg / dL) for women and 420 micromol / liter (6.8 mg / dL) for men  . Hyperuricemia often accompanies diseases such as gout , Lesch-Nyhan syndrome , etc.
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Hyperuricemia develops in connection with a violation of the exchange of purine nucleotides . The reasons for the increased uric acid in the blood are as follows:
- Increased formation of uric acid (with gout; with excessive consumption of purine nitrogenous bases and nucleoproteins with food, coupled with a sedentary lifestyle; and, according to some sources, because of the increased content of fructose in food   ).
- Reduction of renal excretion (excretion) of uric acid as a result of a malfunction of the kidneys (with primary gout, with glomerulonephritis, kidney amyloidosis, alcohol intoxication, etc.).
- Hyperactivation of PRPT-synthetase in violation of the inhibition of its activity.
- Hypoxanthine-guanine-phosphoribosyltransferase deficiency, or HGFRT (an enzyme that provides for the reutilization of purine bases), which manifests itself, for example, in Lyosha-Nihena syndrome . This leads to the fact that hypoxanthine (which was formed as a result of degradation of nucleotides) does not convert to IMP (that is, the recycling processes are disturbed), begins to accumulate and, as a result of consecutive reactions under the action of xanthine oxidase, is converted into uric acid.
- Glycogenosis Girke.
- The drug "Aquaretics".
- The drug " Allopurinol " (200-300 mg orally once a day).
- A diet low in purine bases and nucleoproteins.
- The drug "Febuxostat"  .
- Lesch-Nyhan syndrome
- Monarch Disease Ontology release 2018-06-29sonu
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