Trimedoxime bromide ( lat. Trimedoximi bromidum , Eng. Trimedoxime bromide ) - a drug , a cholinesterase reactant. The structure is close to alloxime .
|IUPAC||1,1'-trimethylene-bis- (4-hydroxyminomethyl-pyridinium bromide) monohydrate or 1,1'-trimethylene-bis- (4-pyridinium-aldoxime) dibromide |
|Gross formula||C 15 H 18 Br 2 N 4 O 2|
|Farmakol. Group||Detoxifying agents, including antidotes |
|injection 150 mg / ml , powder substance |
Slightly yellowish, crystalline powder; odorless, bitter taste. Easily soluble in water, little in alcohol. Aqueous solutions (with the addition of buffer) are pale yellow; pH 3.7-4.2; sterilized at +100 ° C for 30 minutes
The cholinesterase reactant reduces the secretion of gastric juice and the concentration of hydrochloric acid in the gastric juice  .
Organophosphate poisoning, in combination with anticholinergic drugs (atropine, aprofen); prophylactically, in combination with atropine, in the absence of obvious signs of poisoning (after exposure to poison on the body); peptic ulcer of the stomach and duodenum; paroxysmal cardiac arrhythmias - the basis for use are observations of inhibition of tissue activity (acetylcholinesterase) and serum cholinesterase in patients with coronary artery disease and myocardial infarction.
- Side effect
Allergic reactions. [one]
Depending on the severity of poisoning, once or in several doses. At the initial signs of poisoning (agitation, miosis, increased sweating, salivation, the initial phenomena of bronchorrhea) - s / c, 2-3 ml of 0.1% solution of atropine sulfate and 1 ml of 15% solution of trimedoxime bromide. If the symptoms of poisoning do not disappear, atropine and trimedoxime bromide are administered a second time in the same dose. In more severe cases (muscle twitching, cramps, sore spasm or coma, profuse bronchorrhea) - iv up to 3 ml of 0.1% atropine sulfate solution and at the same time i / m or iv 1 ml of 15% solution of trimedoxime bromide. The introduction of atropine in the specified dose is repeated every 5-6 minutes, until the bronchorrhea is completely stopped and signs of atropination appear. If necessary, trimedoxime bromide is administered after 1-2 hours repeatedly; the average dose in severe cases is 3-4 ml of a 15% solution (0.45-0.6 g). In especially severe cases, accompanied by respiratory arrest, up to 7-10 ml. In patients who are in an unconscious state, and if there are difficulties for iv administration of drugs, they can be administered intraglanguage. For relief of paroxysmal cardiac arrhythmias: iv in-stream, 150 mg (1 ml of 15% solution in 10 ml of 0.9% NaCl solution), then in / in dropwise, 2 ml of 15% solution (300 mg) in 100 ml of 0.9% solution NaCl (total 430 mg).
List B. In a dry, cool, dark place. [one]
- Search the database of drugs, search options: INN - Trimedoxime bromide , the flags “Search in the register of registered drugs” , “Search TKFS” , “Show drug forms” unspecified (inaccessible link) . Circulation of drugs . Federal State Institution “Scientific Center for Expertise of Medical Application Tools” of the Russian Healthcare Supervision Service of the Russian Federation (03/27/2008) - A typical clinical and pharmacological article is a by-law and is not protected by copyright in accordance with part four of the Civil Code of the Russian Federation No. 230-FZ of December 18, 2006. Date of treatment March 28, 2008. Archived August 22, 2011.
- Trimedoxime bromide . Register of medicines . ReLeS.ru. Date of treatment March 28, 2008. Archived March 11, 2012.