Diosmectite (dioctahedral smectite) is a substance of natural origin, a mixed aluminum and magnesium silicate (according to other sources, a mixed oxide of silicon and aluminum [1] ). It is used as a medicine, as an enterosorbent .
| Diosmectite | |
|---|---|
| Diosmectit | |
| Chemical compound | |
| IUPAC | Smectite dioctahedral |
| Gross formula | (Na / Ca) 0.33 (Al / Mg) 2 Si 4 O 10 (OH) 2 · (H 2 O) 2 either (Al / Si) 3 O 4 [1] |
| Cas | |
| Classification | |
| ATX | |
| Pharmacokinetics | |
| Excretion | unchanged through the intestines |
| Dosage Forms | |
| powder for oral suspension | |
| Route of administration | |
| orally | |
| Other names | |
| Diosmectite, Neosmectin, Smecta, Dioctahedral smectite | |
Content
- 1 Pharmacological action
- 2 Indications
- 3 notes
- 4 References
Pharmacological action
It stabilizes the mucous barrier, forms polyvalent bonds with mucus glycoproteins , increases the amount of mucus, improves its gastroprotective properties (in relation to the negative effect of hydrogen ions of hydrochloric acid , bile salts, microorganisms and their toxins ). It has selective sorption properties, which are explained by its discoid-crystalline structure; adsorbs microorganisms located in the lumen of the gastrointestinal tract . In therapeutic doses, does not affect intestinal motility. The body is not absorbed and excreted by the intestine unchanged.
Protects the mucous membrane of the digestive tract from the negative effects of hydrogen ions ( hydrochloric acid ), bile salts, viruses, bacteria and their toxins, and other aggressive factors.
Due to adsorption, it reduces the speed and degree of absorption of simultaneously taken drugs, so the interval between taking smectitis and other drugs should be 1-2 hours.
As side effects, constipation , allergic reactions can occur.
Indications
Diarrhea ( allergic , drug genesis; violation of the diet and the quality of food), gastritis , peptic ulcer of the stomach and duodenum , colitis ; diarrhea of infectious origin - as part of complex therapy. Symptomatic treatment of heartburn , flatulence associated with diseases of the gastrointestinal tract.
Contraindicated in case of hypersensitivity , as well as with bowel obstruction .
Notes
- ↑ 1 2 Mashkovsky, 2010 .
Links
- Diosmectite // Medicines / M.D. Mashkovsky . - Reference Mashkovsky on-line . (link broken)